Pharmacological Therapy of Peptic Ulcer

Oh, Jung Hwan

doi:2014.14.1.13

Korean J Helicobacter Up Gastrointest Res > Volume 14(1); 2014 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014;14(1):13-17.
DOI: https://doi.org/10.7704/kjhugr.2014.14.1.13 Published online March 10, 2014.

Pharmacological Therapy of Peptic Ulcer

Jung Hwan Oh

Department of Internal Medicine, St. Paul's Hospital, The Catholic University of Korea, College of Medicine, Seoul, Korea. ojh@catholic.ac.kr

소화성 궤양의 약물치료

오정환

가톨릭대학교 의과대학 성바오로병원 내과학교실

Abstract

Peptic ulcer disease is one of the most commonly encountered diseases. Despite the decrease of Helicobacter pylori infection, the use of aspirin and non-steroidal anti-inflammatory drugs has increased in recent years. Peptic ulcer bleeding is a common emergency associated with high mortality. As an adjunct to endoscopic treatment, acid suppression with proton pump inhibitors (PPIs) is important in the management of peptic ulcer bleeding. A high dose intravenous PPI is effective in reducing rebleeding and the need for surgery. However, data about non-high dose intravenous PPIs are limited. In addition, novel PPIs are focused in this review, since progress has been made regarding new PPIs.

Key Words: Peptic ulcer; Peptic ulcer hemorrhage; Proton pump inhibitors; Therapy