Two Cases of Gastric MALT Lymphoma Diagnosed at Long Last after Successful Eradication of <i>Helicobacter pylori</i>

Yeom, Soo Jeong; Lee, In Seok; Cho, Seok Goo; Choi, Myung Gyu; Choi, Kyu Yong; Park, Gyeong Sin

doi:2012.12.4.265

Korean J Helicobacter Up Gastrointest Res > Volume 12(4); 2012 > Article

Case Report

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2012;12(4):265-270.
DOI: https://doi.org/10.7704/kjhugr.2012.12.4.265 Published online December 10, 2012.

Two Cases of Gastric MALT Lymphoma Diagnosed at Long Last after Successful Eradication of Helicobacter pylori

Soo Jeong Yeom, In Seok Lee, Seok Goo Cho, Myung Gyu Choi, Kyu Yong Choi, Gyeong Sin Park

¹Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. isle@catholic.ac.kr
²Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.

Helicobacter pylori 제균치료 후 장기간 경과 후 발생한 위 MALT 림프종 2예

염수정, 이인석, 조석구, 최명규, 최규용, 박경신¹

가톨릭대학교 의과대학 내과학교실, 병리학교실¹

Abstract

The gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a rare disease. Helicobacter pylori infection is known as an important etiologic factor of the pathogenesis of MALT lymphoma. H. pylori colonization at the epithelium of gastric mucosa induces T cell and B cell recruitment. T cell induced B cell proliferation develops the MALT in the gastric mucosa. Monoclonal proliferation of B cell in the MALT transform into MALT lymphoma. The eradication of H. pylori is known to induce remission of the disease in more than 80% of patients. But there is no report on progression and development of MALT lymphoma after H. pylori eradication. We experienced two cases of gastric B cell MALT lymphoma diagnosed at long last, after the successful eradication of H. pylori.

Key Words: Helicobacter pylori; MALT lymphoma; Eradication