| Effect of DA-9701 on Feeding Inhibition Induced by Acute Restraint Stress in Rats |
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Yong Sung Kim, Moon Young Lee, Jong Seol Park, Eul Sig Choi, Min Seob Kim, Seong Hoon Park, Han Seung Ryu, Suck Chei Choi |
1Department of Gastroenterology, Wonkwang University Sanbon Hospital, Gunpo, Korea.
2Department of Physiology and Institute of Wonkwang Medical Science, Wonkwang University School of Medicine, Iksan, Korea. lmy6774@hanmail.net
3Department of Radiology and Institute for Metabolic Disease, Wonkwang University, Iksan, Korea.
4Department of Gastroenterology, Wonkwang University Hospital, Iksan, Korea.
5Wonkwang Digestive Disease Research Institute, Wonkwang University, Iksan, Korea. |
| 흰쥐에서 급성 구속 스트레스에 의해 유발된 식이억제에 대한 DA-9701의 효과 |
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김용성1,5, 이문영2,5, 박종설1, 최을식2,5, 김민섭2, 박성훈3, 류한승4,5, 최석채4,5 |
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원광대학교 의과대학 산본병원 소화기내과1, 원광대학교 의과대학 생리학교실 및 원광대학교 의과학연구소2, 원광대학교 의과대학 영상의학교실 및 대사성질환연구소3, 원광대학교병원 소화기내과4, 원광대학교 소화기질환연구소5 |
Correspondence:
Moon Young Lee, Tel: +82-63-8506774, Fax: +82-63-8526108,
Email: lmy6774@hanmail.net
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Received: 18 July 2017 • Revised: 3 September 2017 • Accepted: 4 September 2017 |
| Abstract |
BACKGROUND/AIMS
Stress has a role in the pathogenesis of functional dyspepsia (FD) and influences food intake in humans and animals. Prokinetic drugs have been used in FD, and some of these drugs reverse the feeding inhibition (FI) induced by acute restraint stress in rats. We aimed to evaluate the effect of DA-9701 on FI induced by acute restraint in rats. MATERIALS AND METHODS: Male Sprague-Dawley rats were divided into 6 groups: Control (no stress), Stress+vehicle, and Stress+DA-9701 at doses of 1, 3, 10, and 30 mg/kg (n=6~7). DA-9701 or vehicle was administered through gastric gavage 45 minutes before stress. After 60 minutes of stress, pre-weighed chow was given and the weight of remaining food was measured 30 and 60 minutes later. The effect of DA-9701 on FI was compared after pretreatment with WAY100635, a 5HT1A antagonist. RESULTS: The restraint stress group had significantly less food intake than the control group. After feeding, rats given 1 and 3 mg/kg of DA-9701 showed increased food intake at 60 minutes, but this was not statistically significant. Rats given 10 mg/kg of DA-9701 showed significantly increased food intake at 30 minutes and 60 minutes (P < 0.05). Interestingly, rats given 30 mg/kg of DA-9701 showed a significant decrease in food intake, similar to that of the vehicle group. The beneficial effect of 10 mg/kg of DA-9701 on FI was abolished by the pretreatment with WAY100635. CONCLUSIONS: Acute restraint stress reduced food intake in rats and pretreatment with DA-9701 improved stress-induced FI. |
| Key Words:
DA-9701; Dyspepsia; Eating; Rats; Stress, physiological |
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