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Review

September 8, 2023


History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs
Dong Han Yeom, Yong Sung Kim
Korean J Helicobacter  Up Gastrointest Res 2023;23(3):159-166.

Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+, K+-...

Review

September 8, 2023


Role of Potassium-competitive Acid Blockers in the Treatment of Gastric Acid-related Disorders
Mun Young Cho, Yu Kyung Cho
Korean J Helicobacter  Up Gastrointest Res 2023;23(3):167-173.

Owing to their superior pharmacokinetic and pharmacodynamic profiles, potassium-competitive acid blockers (P-CABs) score over proton pump inhibitors (PPIs) in the treatment of gastric acid-related disorders and may provide clinical benefit in the management of these conditions. Previous studies have compared...

Review

September 8, 2023


Potassium-competitive Acid Blockers: A New Therapeutic Strategy for Helicobacter pylori Eradication
Byeong Yun Ahn, Soo-Jeong Cho
Korean J Helicobacter  Up Gastrointest Res 2023;23(3):174-179.

The escalating prevalence of clarithromycin resistance in cases of Helicobacter pylori, insufficient acid suppression, and pharmacodynamic variations secondary to inter-individual differences in CYP2C19 polymorphism collectively contribute to suboptimal eradication rates observed with proton pump inhibitor (PPI)-based therapy. Compared with PPIs,...

Review

September 8, 2023


Optimal Use of Proton Pump Inhibitors and Potassium-competitive Acid Blockers
Jong Kyu Park
Korean J Helicobacter  Up Gastrointest Res 2023;23(3):180-187.

A variety of proton pump inhibitors (PPIs) have been developed in Korea since the introduction of omeprazole (the first PPI) in 1989. PPIs have served as the basic therapeutic approach for the management of gastric acid-related diseases for 30 years...

Original Article

August 30, 2023


Endoscopic Submucosal Dissection for Treatment of Localized Gastric Mucosa-associated Lymphoid Tissue Lymphoma: A Case Series
Jun-young Seo, Kee Don Choi, In Hye Song, et al.
Korean J Helicobacter  Up Gastrointest Res 2023;23(3):188-196.

Background/Aims: The treatment for gastric mucosa-associated lymphoid tissue lymphoma (MALToma) generally involves eradication of Helicobacter pylori. However, MALToma lesions may recur even without H. pylori re-infection. Furthermore, the remission rate of H. pylori-negative MALToma after eradication is low. Therefore, herein,...
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