Trend for Treatment of <i>Helicobacter pylori</i> in Overseas Country

Kang, Ji Hyuk; Lim, Yun Jeong

doi:2012.12.4.224

Korean J Helicobacter Up Gastrointest Res > Volume 12(4); 2012 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2012;12(4):224-231.
DOI: https://doi.org/10.7704/kjhugr.2012.12.4.224 Published online December 10, 2012.

Trend for Treatment of Helicobacter pylori in Overseas Country

Ji Hyuk Kang, Yun Jeong Lim

Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University School of Medicine, Goyang, Korea. limyj@dongguk.ac.kr

헬리코박터 제균 치료의 현재와 미래-국외의 제균 치료 현황

강지혁, 임윤정

동국대학교 의과대학 일산병원 내과학교실

Abstract

Management of Helicobacter pylori infection is still a challenging matter. The aim of eradication of H. pylori is to cure peptic ulcer and decrease the risk of gastric cancer. The prevalence of H. pylori infection is high in developing countries and the burden of gastric cancer in developing countries is large since H. pylori has the potential to increase the risk of gastric cancer. Over the past decade, the efficacy of the standard first-line triple therapy has declined and increased resistance to antibiotics, especially clarithromycin, is considered the most important cause. Attempts to overcome eradication failure have been made. Sequential therapy, quadruple therapy and various combinations of new (quinolone or rifabutin) and old antibiotics have been introduced. This review will give an overview on the dramatic fall in eradication rates all over the world and introduce newer attempts providing promising results.

Key Words: Helicobacter pylori; Eradication; Antibiotic resistance